TAN 420E

TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay (IC50 = 1.3 µM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 µg/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 µg/ml). It is cytotoxic to P388 and KB cancer cells (EC50s = 0.022 and 0.3 µg/ml, respectively).Formal Name: (15R)-18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-11-O-methyl-geldanamycin. CAS Number: 91700-93-5. Synonyms: Dihydroherbimycin A. Molecular Formula: C30H44N2O9. Formula Weight: 576.7. Purity: >95%. Formulation: (Request formulation change), A lyophilisate. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: OC1=CC(N2)=C(O)C([C@@](OC)([H])[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)=C1. InChi Code: InChI=1S/C30H44N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28,33-34H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9+,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1. InChi Key: QANBQEQVJJKJTJ-GDYSMBPZSA-N. Origin: Bacterium/Streptomyces sp..