TAMRA-PEG4-tetrazine

Description: TAMRA-PEG4-tetrazine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Target: Others. Smiles: [O-]C(C(C=C(C(NCCOCCOCCO CCOCCC(NCC1=CC=C(C2=NN=CN=N2)C=C1)=O)=O)C=C3)=C3C4=C(C=CC(N(C)C)=C5)C5=[O+]C6=C4C=CC(N(C)C)=C6)=O.[O-]C(C7=C(C8=C9C=CC(N(C)C)=CC9=[O+]C%10=C8C=CC(N(C)C)=C%10)C=C(C(NCCOCCOCCOCCOCCC(NCC%11=CC=C(C=C%11)C%12=NN=CN=N%12)=O)=O)C=C7)=O. References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct,36:553-562.