Talarozole

Description: Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) that inhibits CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively, for treating acne, psoriasis, and other keratinization disorders. Target: Others, Autophagy, Retinoid Receptor, P450. Smiles: CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1. References: Elizabeth Pavez Loriè, Chamcheu J C , Vahlquist A , et al. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis[J]. Archives of Dermatological Research, 2009, 301(7):475-485.