TAK-653

An AMPA receptor positive allosteric modulator, increases glutamate-induced calcium influx in CHO cells expressing human AMPA receptors (EC50 = 3.3 µM), potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons (EC50= 4.4 µM), ameliorates MK-801-induced working memory deficits in the radial arm maze task in rats from 0.1-10 mg/kg, increases DMTS accuracy in cynomolgus monkeys at 0.06 mg/kg. Formulation: A solid. InChI: InChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3. InChIKey: PXJBHEHFVQVDDS-UHFFFAOYSA-N. SMILES: O=S1(N=C2C(C3=CC=C(C=C3)OC4CCCCC4)=NC(C)=CN2CC1)=O