TA-02

TA-02 is a derivative of the p38 MAPK inhibitor SB 203580 (Cay-13067, Cay-13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic, increasing expression of the cardiomyocyte marker NKX2-5 by greater than 2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation at a concentration of 5 µM. TA-02 inhibits casein kinase 1epsilon (CK1epsilon) and CK1D and reduces expression of Wnt/beta-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.Formal Name: 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-pyridine. CAS Number: 1784751-19-4. Molecular Formula: C20H13F2N3. Formula Weight: 333.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml, DMSO: 3 mg/ml. lambdamax: 203, 298 nm. SMILES: FC1=CC=CC=C1C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2. InChi Code: InChI=1S/C20H13F2N3/c21-15-7-5-13(6-8-15)18-19(14-9-11-23-12-10-14)25-20(24-18)16-3-1-2-4-17(16)22/h1-12H,(H,24,25). InChi Key: QIFJOFNVIVQRNJ-UHFFFAOYSA-N.