TA-01

Description: TA-01 is a potent inhibitor of CK1 and p38 MAPK, with IC50 values of 6.4 nM for CK1epsilon, 6.8 nM for CK1delta, and 6.7 nM for p38 MAPK. Target: Casein Kinase, p38 MAPK, Autophagy. Smiles: Fc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1c(F)cccc1F. References: Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar,80:56-70.