t-TUCB

t-TUCB is a soluble epoxide hydrolase (sEH) inhibitor (IC50s = 0.4, 3.1, and 11.9 nM for the human, mouse, and rat enzymes, respectively). It also inhibits fatty acid amide hydrolase (FAAH, IC50 = 260 nM for the human enzyme). t-TUCB (3 mg/kg) increases the mechanical paw withdrawal threshold in a mouse model of diabetic neuropathic pain induced by streptozotocin (Cay-13104). It prevents EKG abnormalities induced by the beta1- and beta2-adrenergic receptor agonist isoproterenol (Cay-15592), as well as reduces isoproterenol-induced increases in infarct size and heart weight, in a rat model of myocardial ischemia when administered at doses of 3, 10, and 30 mg/kg.Formal Name: 4-[[trans-4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]-benzoic acid. CAS Number: 948304-40-3. Molecular Formula: C21H21F3N2O5. Formula Weight: 438.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 247 nm. SMILES: FC(F)(F)OC(C=C1)=CC=C1NC(N[C@H](CC2)CC[C@@H]2OC3=CC=C(C=C3)C(O)=O)=O. InChi Code: InChI=1S/C21H21F3N2O5/c22-21(23,24)31-18-11-5-15(6-12-18)26-20(29)25-14-3-9-17(10-4-14)30-16-7-1-13(2-8-16)19(27)28/h1-2,5-8,11-12,14,17H,3-4,9-10H2,(H,27,28)(H2,25,26,29)/t14-,17-. InChi Key: XDVFKCZZXOGEMN-CZIWCDLHSA-N.