Sulbactam

Description: Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity. Target: Antibacterial, Antibiotic. Smiles: [Na+].[H][C@@]12CC(=O)N1C(C([O-])=O)C(C)(C)S2(=O)=O. References: Singh GS, et al. Mini Rev Med Chem. 2004 Jan,4(1):93-109.