Streptochlorin

Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-alpha-induced NF-kappaB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 µM. Streptochlorin (12 µg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 µM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-alpha and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).Formal Name: 3-(4-chloro-5-oxazolyl)-1H-indole. CAS Number: 120191-51-7. Synonyms: SF 2583A. Molecular Formula: C11H7ClN2O. Formula Weight: 218.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. lambdamax: 222, 272, 288 nm. SMILES: ClC(N=CO1)=C1C2=CNC3=CC=CC=C32. InChi Code: InChI=1S/C11H7ClN2O/c12-11-10(15-6-14-11)8-5-13-9-4-2-1-3-7(8)9/h1-6,13H. InChi Key: BKYJGKRXUHPPLR-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces roseolilacinus.