Stauprimide

Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 µM). It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-Myc, a key regulator of pluripotency.Formal Name: N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-benzamide. CAS Number: 154589-96-5. Synonyms: N-Benzoyl-7-oxo Staurosporine. Molecular Formula: C35H28N4O5. Formula Weight: 584.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 239, 287, 317, 412 nm. SMILES: [H][C@]12N(C3=C4C5=C(C(NC5=O)=O)C6=C3N([C@](O2)(C)[C@H](OC)[C@H](N(C)C(C7=CC=CC=C7)=O)C1)C8=C6C=CC=C8)C9=C4C=CC=C9. InChi Code: InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1. InChi Key: MQCCJEYZKWZQHU-MPRCCEKMSA-N.