Statil

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2alpha by human cultured preadipocytes.Formal Name: 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid. CAS Number: 72702-95-5. Synonyms: ICI 128436, MK-538, Ponalrestat. Molecular Formula: C17H12BrFN2O3. Formula Weight: 391.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/mL, DMSO: 2 mg/mL, Ethanol: 2 mg/mL, PBS (pH 7.2): 0.2 mg/mL. lambdamax: 212, 256, 288 nm. SMILES: BrC1=CC=C(CN2C(C(C=CC=C3)=C3C(CC(O)=O)=N2)=O)C(F)=C1. InChi Code: InChI=1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23). InChi Key: LKBFFDOJUKLQNY-UHFFFAOYSA-N.