Sporogen-AO 1

Description: Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 µM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 µM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3. Target: Others. Smiles: [H][C@]12O[C@@]1(C(C)=C)C(=O)C=C1CC[C@@H](O)[C@H](C)[C@@]21C , t:10, . References: Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(51)5907-5910(1984)