SPI--112Me

Description: SPI--112Me, a prodrug of SPI-112, preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by more than 20-fold in cell-free assays. Target: Others. Smiles: N(\NC1=CC(C(OC)=O)=CC=C1)=C\2/C=3C(NC2=O)=CC=C(S(NCC4=CC=C(F)C=C4)(=O)=O)C3. References: Win-Piazza, H., Schneeberger, V., Chen, L., Pernazza, D., Lawrence, H., & Sebti, S. et al. (2012). Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2. Send To Cancer Lett, 320(1), 81-5. doi: 10.1016/j.canlet.2012.01.034