Sp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)

Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-alpha-S) is an isomer of the sulfur-containing nucleotide derivative ATP-alpha-S and an agonist of the purinergic P2Y1 receptor. It increases calcium mobilization in HEK293 cells expressing the P2Y1 receptor (EC50 = 9.4 nM for the human receptor). Sp-ATP-alpha-S inhibits ADP-induced aggregation of isolated human platelets (Ki = 4 µM). It induces relaxation of carbamoylcholine-preconstricted guinea pig taenia coli (EC50 = 426 nM).Formal Name: adenosine, 5'->P''-ester with (P''S)-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt. Synonyms: Sp-ATP-alpha-S. Molecular Formula: C10H12N5O12P3S . 4Na. Formula Weight: 611.2. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O[C@@H]1[C@@H](CO[P@@](OP(OP([O-])([O-])=O)([O-])=O)([S-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H16N5O12P3S.4Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-30(23,31)27-29(21,22)26-28(18,19)20,,,,/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,31)(H2,11,12,13)(H2,18,19,20),,,,/q,4*+1/p-4/t4-,6-,7-,10-,30+,,,,/m1..../s1. InChi Key: YDIKIZFBYNZKKC-KBTDCMGGSA-J.