Sofalcone

Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-alpha, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 µM. Sofalcone (20-50 µM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.Formal Name: 2-[5-[(3-methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-acetic acid. CAS Number: 64506-49-6. Synonyms: Solon, SU 88. Molecular Formula: C27H30O6. Formula Weight: 450.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMSO: 16 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 238, 348 nm. SMILES: C/C(C)=C\COC1=CC(OCC(O)=O)=C(C(/C=C/C2=CC=C(OC/C=C(C)\C)C=C2)=O)C=C1. InChi Code: InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+. InChi Key: GFWRVVCDTLRWPK-KPKJPENVSA-N.