SKF-96365 hydrochloride

Description: SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIgamma (CaMKIIgamma)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIgamma or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIgamma/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner. Target: Potassium Channel, Autophagy, Calcium Channel, TRP/TRPV Channel, Apoptosis. Smiles: Cl.COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1. References: Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475.