SKF 96365 (hydrochloride)

SKF 96365 inhibits the receptor-mediated influx of calcium via voltage-gated calcium channels with an IC50 value of approximately 10 µM. It inhibits the acetylcholine-induced depolarization of circular smooth muscle in a dose-dependent manner at 3-50 µM. SKF 96365 can distinguish receptor-mediated release in platelets and neutrophils from the calcium release from internal stores. However, it does not distinguish between receptor-mediated and voltage-gated release.Formal Name: 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole, monohydrochloride. CAS Number: 130495-35-1. Molecular Formula: C22H26N2O3 . HCl. Formula Weight: 402.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 226, 275 nm. SMILES: COC1=CC=C(C=C1)C(OCCCC2=CC=C(OC)C=C2)CN3C=NC=C3.Cl. InChi Code: InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19,/h5-14,17,22H,3-4,15-16H2,1-2H3,1H. InChi Key: FWLPKVQUECFKSW-UHFFFAOYSA-N.