Simvastatin . sodium salt

White to off-white powder. Soluble in water (30mg/ml). Soluble in DMSO, ethanol or DMF (all 10mg/ml). Chemical. CAS: 101314-97-0. Formula: C25H39O6 . Na. MW: 458.6. Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051 http://www.adipogen.com/ag-cn2-0051/lovastatin.html ). Water-soluble carboxylate form of Simvastatin (Prod.No. AG-CN2-0052 https://adipogen.com/ag-cn2-0052-simvastatin.html ). Potent competitive HMG-CoA reductase inhibitor [1]. Anti-hypercholesterolemic agent [1]. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids [1, 2]. Inhibits the isoprenylation of Ras and Rho family GTPases [2]. Smooth muscle cell proliferation inhibitor [3]. Anti-adhesive, immunomodulatory and anti-inflammatory compound [4, 7, 10]. Proteasome modulator [5]. Stimulates bone formation [6]. Apoptosis inducer [8]. Anticancer compound [8, 9]. Increases cellular resistance to anticancer agents such as doxorubicin and etoposides (Prod. No. AG-CR1-3572 http://www.adipogen.com/ag-cr1-3572/etoposide.html ) [9]. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection [11, 12]. Anti-hypertensive agent [13]. Suppresses TNF-induced NF-kappaB activation [14].