Simufilam dihydrochloride

Description: Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its alpha7nAChR/TLR4 associations and downstream pathologies. Target: Others. Smiles: [H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl. References: Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017,55:99-114.