SIH

SIH is a lipophilic cell-permeable iron chelator. It stimulates iron release from, and inhibits iron uptake by, SK-N-MC human neuroblastoma cells when used at a concentration of 25 µM. SIH inhibits cumene hydroperoxide-induced membrane lipid peroxidation but not ABAP-induced formation of cytosolic peroxyl radicals in HepG2 human hepatocellular carcinoma cells (IC50s = 0.833 and >4,000 µM, respectively). It inhibits hydrogen peroxide-induced mitochondrial membrane depolarization in H9c2 rat cardiomyocytes (EC50 = 0.8 µM). SIH (1.0 mg/kg) completely prevents mortality in a rabbit model of cardiotoxicity induced by chronic administration of daunorubicin (Cay-14159).Formal Name: 2-[(2-hydroxyphenyl)methylene]hydrazide 4-pyridinecarboxylic acid. CAS Number: 495-84-1. Synonyms: NSC 33760, Salicylaldehyde Isonicotinoyl Hydrazine, Salinazid. Molecular Formula: C13H11N3O2. Formula Weight: 241.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.23 mg/ml, DMSO: 5 mg/ml. lambdamax: 215, 290, 335 nm. SMILES: O=C(C1=CC=NC=C1)NN=CC2=C(O)C=CC=C2. InChi Code: InChI=1S/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18). InChi Key: VBIZUNYMJSPHBH-UHFFFAOYSA-N.