SID 7969543

SID 7969543 is an inhibitor of nuclear receptor subfamily 5 group A member 1 (NR5A1), also known as steroidogenic factor 1 (SF-1, IC50 = 760 nM). It is selective for NR5A1/SF-1 over retinoic acid receptor-related orphan receptor alpha (RORalpha) and the herpes simplex virus (HSV) transcriptional activator VP16 (IC50s = >33.333 µM for both). SID 7969543 is selectively cytotoxic to PER-485, THP-1, and MOLM-13 leukemia cells, which contain mixed-lineage leukemia 1 (MLL1) rearrangement mutations (IC50s = 1.4, 2.6, and 1 µM, respectively), over a panel of wild-type MLL1-containing leukemia cells and MRC-5 fibroblasts (IC50s = >20 µM for all). SMILES O=C(NC1=CC=C2OCCOC2=C1)CN3C=CC4=C(C=CC=C4OC(C(OCC)=O)C)C3=O InChi Code InChI=1S/C24H24N2O7/c1-3-30-24(29)15(2)33-19-6-4-5-18-17(19)9-10-26(23(18)28)14-22(27)25-16-7-8-20-21(13-16)32-12-11-31-20/h4-10,13,15H,3,11-12,14H2,1-2H3,(H,25,27) InChi Key KWMBIIQCLUIHDI-UHFFFAOYSA-N