Shikonin

Description: Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 µM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities. Target: TNF, PKM, Chloride channel, HIV Protease, NF-kappaB. Smiles: CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O. References: Zhang FY, et al. Shikonin Inhibits the Migration and Invasion of Human Glioblastoma Cells by Targeting Phosphorylated beta-Catenin and Phosphorylated PI3K/Akt: A Potential Mechanism for the Anti-Glioma Efficacy of a Traditional Chinese Herbal Medicine. Int J Mol Sci. 2015 Oct 9,16(10):23823-48.