Sevoflurane

Sevoflurane is a halogenated ether with anesthetic properties. It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of alpha2beta1 subunit-containing GABAA and alpha1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively). Sevoflurane (360 µM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an alpha1beta2gamma2 subunit composition. It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM). Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.Formal Name: 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propane. CAS Number: 28523-86-6. Synonyms: Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl ester, Fluoromethyl 1,1,1,3,3,3-Hexafluoro-2-propyl ester. Molecular Formula: C4H3F7O. Formula Weight: 200.1. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: miscible, DMSO: miscible, Ethanol: miscible, PBS (pH 7.2): miscible. SMILES: FCOC(C(F)(F)F)C(F)(F)F. InChi Code: InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2. InChi Key: DFEYYRMXOJXZRJ-UHFFFAOYSA-N.