Securinine (Securinan-11-one)

Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity. Synonyms: (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 1,2,3,4,10,10a-Hexahydro-10-hydroxy-6,10-methanopyrido [1,2-a]azepine-9(6H),alpha-acetic Acid gamma-Lactone, Securinan-11-one, (-)-Securinine, NSC 107413, Securinin, l-Securinine, CAS Number: 5610-40-2, Molecular Formula: C??H??NO?, Molecular Weight: 217.26, Form: Supplied as a pale yellow to yellow solid, Melting Point: 140-144°C, Solubility: Chloroform (slightly), Ethanol (slightly), Method for Determining Identity: Proton NMR (CD3OD) and Mass Spectrometric Analysis, TLC Conditions: SiO2, Dichloromethane: Methanol= 9:1, Visualized with UV KMnO4, Single Spot, Rf=0.35. Elemental Analysis: Calculated: %C:71.87, %H:6.96, %N:6.45, Specific Rotation (c=0.50, Ethanol): -1066.6°, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.