Secoxyloganin

Secoxyloganin is a secoiridoid glycoside that has been found in L. japonica and has diverse biological activities. It is active against E. coli and S. aureus in a disc assay when used at a concentration of 2 mg/disc. Secoxyloganin is cytotoxic to human dermal fibroblasts (IC50 = 78.1 µM). In vivo, secoxyloganin (10 mg/ml) prevents hen egg white lysozyme-induced decreases in tail vein blood flow, a marker of allergic inflammation, in hen egg white lysozyme-sensitized mice.Formal Name: (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid. CAS Number: 58822-47-2. Molecular Formula: C17H24O11. Formula Weight: 404.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL, Ethanol: 10mg/mL, PBS (pH 7.2): 10mg/mL. lambdamax: 232 nm. SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](C=C)[C@H](CC(O)=O)C(C(OC)=O)=CO2)O1. InChi Code: InChI=1S/C17H24O11/c1-3-7-8(4-11(19)20)9(15(24)25-2)6-26-16(7)28-17-14(23)13(22)12(21)10(5-18)27-17/h3,6-8,10,12-14,16-18,21-23H,1,4-5H2,2H3,(H,19,20)/t7-,8+,10-,12-,13+,14-,16+,17+/m1/s1. InChi Key: MQLSOVRLZHTATK-PEYNGXJCSA-N. Origin: Plant/Lonicerae flos.