Scutellarein

Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 µg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal alpha-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 µM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-alpha induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 µM. In vivo, scutellarein (0.5 µg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.Formal Name: 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 529-53-3. Synonyms: 6-Hydroxyapigenin. Molecular Formula: C15H10O6. Formula Weight: 286.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 219, 338 nm. SMILES: OC1=C(O)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1. InChi Code: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H. InChi Key: JVXZRQGOGOXCEC-UHFFFAOYSA-N.