Sclerotiorin

Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 µM. Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),, inhibition of Grb2-Shc interaction (IC50 = 22 µM),, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).Formal Name: 7-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6H-2-benzopyran-6,8(7H)-dione. CAS Number: 549-23-5. Molecular Formula: C21H23ClO5. Formula Weight: 390.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml, Ethanol: 3 mg/ml. lambdamax: 206, 287, 365 nm. SMILES: O=C1C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C(Cl)C([C@]1(C)OC(C)=O)=O. InChi Code: InChI=1S/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1. InChi Key: SWJLTKXURNHVHE-UPWXJBBJSA-N. Origin: Fungus/Penicillium sp..