Sclareol

Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities. It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 µg/ml, respectively). Sclareol (5 and 10 µg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages. It reduces lambda-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 µM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 µM. Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.Formal Name: (alphaR,1R,2R,4aS,8aS)-alpha-ethenyldecahydro-2-hydroxy-alpha,2,5,5,8a-pentamethyl-1-naphthalenepropanol. CAS Number: 515-03-7. Synonyms: (-)-Sclareol. Molecular Formula: C20H36O2. Formula Weight: 308.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 30 mg/ml. SMILES: CC1(C)CCC[C@]2(C)[C@@H](CC[C@@](C)(O)C=C)[C@](C)(O)CC[C@]21[H]. InChi Code: InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1. InChi Key: XVULBTBTFGYVRC-HHUCQEJWSA-N. Origin: Plant/Salvia sclarea.