Sciadopitysin

Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-beta (1-42) (Abeta42, Cay-20574) in PC12 cells (EC50 = 9.84 µM). Sciadopitysin (0.1-10 µM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic beta-cells. It inhibits P-glycoprotein (P-gp, IC50 = 53.42 µM) and increases cellular toxicity of paraquat and paclitaxel (Cay-10461) in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-kappaB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.Formal Name: 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 521-34-6. Synonyms: NSC 45108. Molecular Formula: C33H24O10. Formula Weight: 580.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 12 mg/ml, DMSO: 12 mg/ml, Ethanol: partially soluble, PBS (pH 7.2): partially soluble. lambdamax: 213, 273, 323 nm. SMILES: OC1=CC(O)=C2C(OC(C3=CC=C(OC)C=C3)=CC2=O)=C1C4=CC(C(OC5=C6C(O)=CC(OC)=C5)=CC6=O)=CC=C4OC. InChi Code: InChI=1S/C33H24O10/c1-39-18-7-4-16(5-8-18)27-15-25(38)32-23(36)13-22(35)30(33(32)43-27)20-10-17(6-9-26(20)41-3)28-14-24(37)31-21(34)11-19(40-2)12-29(31)42-28/h4-15,34-36H,1-3H3. InChi Key: YCXRBCHEOFVYEN-UHFFFAOYSA-N. Origin: Plant/Ginkgo biloba L..