SB-4

SB-4 is an activator of bone morphogenetic protein 4 (BMP4) signaling. It induces BMP4 signaling in a reporter assay using HEK293 cells expressing a recombinant human BMP4 response element (EC50 = 74 nM). SB-4 (10 µM) increases phosphorylation of SMAD1, -5, and -9 in HEK293 cells. It also induces Blimp1 and Tfap2c expression, markers of germline differentiation, in mouse embryonic stem cells.Formal Name: 2-[[(4-bromophenyl)methyl]thio]-benzoxazole. CAS Number: 100874-08-6. Molecular Formula: C14H10BrNOS. Formula Weight: 320.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: BrC1=CC=C(CSC2=NC3=C(O2)C=CC=C3)C=C1. InChi Code: InChI=1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2. InChi Key: JDVOIBFEFVKUPL-UHFFFAOYSA-N.