SB 203580 sulfone

Description: SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 µM for IL-1 inhibition and 0.03 µM for CSBP-mediated signaling inhibition [1]. Target: Others. Smiles: FC1=CC=C(C2=C(N=C(N2)C3=CC=C(S(C)(=O)=O)C=C3)C=4C=CN=CC4)C=C1