Sardomozide (hydrochloride)

Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), an enzyme involved in polyamine biosynthesis (IC50 = 0.005 µM for the rat liver enzyme). It is selective for SAMDC over diamine oxidase (DAO, IC50 = 18 µM for the rat small intestine enzyme). Sardomozide inhibits the proliferation of T24 bladder cancer cells (IC50 = 0.71 µM). It decreases intracellular levels of spermidine and spermine and increases intracellular putrescine levels in L1210 murine leukemia cells when used at a concentration of 3 µM. Sardomozide (0.2 and 0.4 µM) inhibits HIV-1 replication in PM1 cells. It reduces tumor growth in a SK-MEL-24 melanoma mouse xenograft model when administered at doses of 0.5 and 5 mg/kg.Formal Name: 2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]-hydrazinecarboximidamide, dihydrochloride. CAS Number: 138794-73-7. Synonyms: CGP 48664, SAM486A. Molecular Formula: C11H14N6 . 2HCl. Formula Weight: 303.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: soluble. lambdamax: 232, 272, 281, 309 nm. SMILES: N=C(N/N=C1C2=CC=CC(C(N)=N)=C2CC/1)N.Cl.Cl. InChi Code: InChI=1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15,,/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17),2*1H/b16-9+,,. InChi Key: UHEIPGJSFDAPIC-NENXIMLWSA-N.