Sapacitabine

Sapacitabine is a prodrug form of the nucleoside derivative CNDAC (Cay-40672). In vivo, sapacitabine (5 and 15 mg/kg) reduces tumor volume in an MV4-11 mouse xenograft model when administered alone or in combination with the histone deacetylase (HDAC) inhibitor SAHA (vorinostat, Cay-10009929).Formal Name: N-[1-(2-cyano-2-deoxy-b-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-hexadecanamide. CAS Number: 151823-14-2. Synonyms: CS 682, CYC-682. Molecular Formula: C26H42N4O5. Formula Weight: 490.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2C#N)C=CC(NC(CCCCCCCCCCCCCCC)=O)=N1. InChi Code: InChI=1S/C26H42N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-23(32)28-22-16-17-30(26(34)29-22)25-20(18-27)24(33)21(19-31)35-25/h16-17,20-21,24-25,31,33H,2-15,19H2,1H3,(H,28,29,32,34)/t20?,21-,24+,25-/m1/s1. InChi Key: LBGFKUUHOPIEMA-HFPBRLNESA-N.