Sanguinarine (chloride)

Sanguinarine is a benzylisoquinoline alkaloid isolated from plants belonging to the family Papaveraceae. It exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines. Sanguinarine suppresses NF-kappaB activation by blocking the degradation of IkappaBalpha and sensitizes cancer cells to apoptosis by inducing ROS generation and activating TNF-related apoptosis-inducing ligand. Furthermore, sanguinarine has been shown to reduce cancer cell metastasis though the inhibition of MMP-2 and MMP-9 activation and to exhibit antiangiogenic activity by downregulating VEGF-induced Akt activation.Formal Name: 13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, monochloride. CAS Number: 5578-73-4. Molecular Formula: C20H14NO4 . Cl. Formula Weight: 367.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: 5 mg/ml. lambdamax: 216, 235, 276, 328, 402, 472 nm. SMILES: C[N+]1=CC2=C(C=CC3=C2OCO3)C4=C1C5=CC(OCO6)=C6C=C5C=C4.[Cl-]. InChi Code: InChI=1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21,/h2-8H,9-10H2,1H3,1H/q+1,/p-1. InChi Key: GIZKAXHWLRYMLE-UHFFFAOYSA-M.