SAICAR

Description: SAICAR, an intermediate of de novo purine nucleotide biosynthesis, selectively activates pyruvate kinase isoform M2 (PKM2) with an EC50 of 0.3 mM. Target: Others. Smiles: NC=1N(C=NC1C(N[C@@H](CC(O)=O)C(O)=O)=O)[C@@]2(O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)[H]. References: Keller KE, et al. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. Mol Cell. 2014 Mar 6,53(5):700-9.