Sacubitril/Valsartan

Description: Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure. Target: Neprilysin, RAAS, Apoptosis. Smiles: CC(C)[C@@H](C([O-])=O)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=N[N-]3)C=CC=C2.CCOC([C@H](C)C[C@H](NC(CCC([O-])=O)=O)CC4=CC=C(C5=CC=CC=C5)C=C4)=O.[Na+].O.[Na+].[Na+].O. References: Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12,11(5):e20154605.