RP 1664

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay44283-1	1 mg	-	6 - 10 Werktage*	186,00 €
Cay44283-5	5 mg	-	6 - 10 Werktage*	881,00 €
Cay44283-10	10 mg	-	6 - 10 Werktage*	1.668,00 €

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RP 1664 is an inhibitor of polo-like kinase 4 (Plk4, IC50 = 3 nM). It induces centriole depletion... mehr

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Produktinformationen "RP 1664"

RP 1664 is an inhibitor of polo-like kinase 4 (Plk4, IC50 = 3 nM). It induces centriole depletion in hTERT RPE-1 retinal pigment cells (EC50 = 0. µM). RP 1664 induces cytotoxicity in MCF-7 breast cancer cells (EC50 = 0. µM). It reduces tumor volume in a CAL-148 breast cancer mouse xenograft model when administered at doses of 11 or 21 mg/kg twice per day. InChI: InChI=1S/C23H24F2N8O2S/c1-12-7-18(31-30-12)27-22-19(13-5-6-13)20(17-10-32(2)11-26-17)28-23(29-22)33(3)21-15(24)8-14(9-16(21)25)36(4,34)35/h7-11,13H,5-6H2,1-4H3,(H2,27,28,29,30,31), InChIKey: POKVQQVLRJLUAK-UHFFFAOYSA-N, SMILES: CC1=CC(NC2=C(C3CC3)C(C4=CN(C)C=N4)=NC(N(C(C(F)=CC(S(C)(=O)=O)=C5)=C5F)C)=N2)=NN1

Schlagworte:	5-cyclopropyl-N2-(2,6-difluoro-4-(methylsulfonyl)phenyl)-N2-methyl-6-(1-methyl-1H-imidazol-4-yl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Hersteller:	Cayman Chemical
Hersteller-Nr:	44283

Eigenschaften

Anwendung:	Plk4 inhibitor
MW:	514.56 D
Formel:	C23H24F2N8O2S
Reinheit:	>95%
Format:	Solid

Datenbank Information

CAS :	2980682-00-4\| Passende Produkte
KEGG ID :	K08863 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	+20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H302, H315, H319, H335
P-Sätze:	P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501