Ronidazole

Ronidazole is a carbamate ester with antiprotozoal and antibiotic activities. It is active against a panel of T. foetus isolates with minimum lethal concentrations (MLCs) ranging from 0.625 to 1.25 µg/ml. It is also active against C. difficile bacteria (MIC90 = 0.125 µg/ml). Ronidazole (50 mg/kg) inhibits infection relapse in a cat model of experimental T. foetus infection. It also inhibits T. muris infection in mice when administered at a concentration of 400 mg/L in drinking water. Ronidazole (10 mg/kg) increases survival in a mouse model of C. difficile infection. Formulations containing ronidazole have been used in the treatment of T. foetus infection in cats.Formal Name: 1-methyl-5-nitro-1H-imidazole-2-methanol, 2-carbamate. CAS Number: 7681-76-7. Synonyms: Ridzol. Molecular Formula: C6H8N4O4. Formula Weight: 200.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 301 nm. SMILES: O=C(N)OCC1=NC=C([N+]([O-])=O)N1C. InChi Code: InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11). InChi Key: PQFRTXSWDXZRRS-UHFFFAOYSA-N.