ROC-325

ROC-325 is an autophagy inhibitor. It inhibits autophagic flux and induces lysosomal deacidification and apoptosis in 786-O renal cell carcinoma cells when used at a concentration of 5 µM. ROC-325 decreases viability in a panel of 12 cancer cell lines, including renal, lung, pancreatic, and prostate cancer cells, with IC50 values ranging from 4.9 to 11 µM. It reduces tumor growth in a 786-O mouse xenograft model when administered at a dose of 50 mg/kg. ROC-325 also decreases the cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected Vero E6 cells (EC50 = 3.28 µM).Formal Name: 1-[[2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]methylamino]ethyl]amino]-4-methyl-9H-thioxanthen-9-one. CAS Number: 1859141-26-6. Molecular Formula: C28H27ClN4OS. Formula Weight: 503.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 10 mg/ml, DMF: slightly soluble, DMSO: slightly soluble, Ethanol: slightly soluble. lambdamax: 220, 257 nm. SMILES: O=C1C2=C(SC3=C1C(NCCN(CCNC4=C5C=CC(Cl)=CC5=NC=C4)C)=CC=C3C)C=CC=C2. InChi Code: InChI=1S/C28H27ClN4OS/c1-18-7-10-23(26-27(34)21-5-3-4-6-25(21)35-28(18)26)32-14-16-33(2)15-13-31-22-11-12-30-24-17-19(29)8-9-20(22)24/h3-12,17,32H,13-16H2,1-2H3,(H,30,31). InChi Key: HXUYKEGAEIYPKY-UHFFFAOYSA-N.