Ro 08-2750

Description: Ro 08-2750 is a non-peptide, reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 µM. It is also a selective MSI RNA-binding activity inhibitor, exhibiting an IC50 of 2.7 µM. Additionally, Ro 08-2750 selectively inhibits NGF binding to p75NTR over TRKA. Target: Others. Smiles: Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O. References: Arkin MR, et al. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr,3(4):301-17.