RNF5 inhibitor inh-02

Description: RNF5 inhibitor inh-02, a potent E3 ubiquitin ligase RNF5/RMA1 inhibitor, demonstrates significant efficacy in rescuing F508del-CFTR with an EC50 of 2.2 uM in bronchial epithelial cells homozygous for the F508del mutation. This compound is valuable for cystic fibrosis research[1]. Target: Others. Smiles: N(C(=NC1=CC=CC=C1)C2=CC=CC=C2)=C3N(CC4=CC=CC=C4)C(C)=NS3. References: Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19,25(7):891-905.e8.