RN-1734

Description: RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 µM,5.9 µM,3.2 µM for hTRPV4, mTRPV4 and rTRPV4,respectively). Target: TRP/TRPV Channel. Smiles: S(N(CCNC(C)C)C(C)C)(=O)(=O)C1=C(Cl)C=C(Cl)C=C1. References: Kato K , Morita I . Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: A study to elucidate the action points of acidosis and search for putative target molecules[J]. European Journal of Pharmacology, 2011, 663(1-3):27-39.