Rilpivirine

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Cay-18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.Formal Name: 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-benzonitrile. CAS Number: 500287-72-9. Synonyms: R278474, TMC278. Molecular Formula: C22H18N6. Formula Weight: 366.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.3 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 0.2 mg/ml. lambdamax: 306 nm. SMILES: CC1=CC(/C=C/C#N)=CC(C)=C1NC2=NC(NC3=CC=C(C#N)C=C3)=NC=C2. InChi Code: InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+. InChi Key: YIBOMRUWOWDFLG-ONEGZZNKSA-N.