Rhoifolin

Rhoifolin is a flavonoid glycoside that has been found in C. nudiflora and has diverse biological activities. It inhibits Ezrin phosphorylation, cell migration, and TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) in MDA-MB-231 cells when used at concentrations of 10 and 40 µM. Rhoifolin inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro, IC50 = 27.45 µM). It reverses scopolamine-induced memory deficits and inhibits acetylcholinesterase (AChE) activity in zebrafish when administered in the tank water at concentrations of 1, 3, and 5 µg/L. Rhoifolin (20 and 40 mg/kg) reduces paw edema and IL-1beta, IL-6, and TNF-alpha levels in a rat model of carrageenan-induced inflammation. It also ameliorates cartilage damage in a rat model of osteoarthritis, an effect that can be reversed by the autophagy inhibitor 3-methyladenine (Cay-13242).Formal Name: 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 17306-46-6. Synonyms: Apigenin 7-O-Neohesperidoside. Molecular Formula: C27H30O14. Formula Weight: 578.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 268, 334 nm. SMILES: O=C1C2=C(O)C=C(O[C@H]3[C@H](O[C@]4([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2OC(C5=CC=C(O)C=C5)=C1. InChi Code: InChI=1S/C27H30O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-8,10,18,20-30,32-36H,9H2,1H3/t10-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1. InChi Key: RPMNUQRUHXIGHK-PYXJVEIZSA-N. Origin: Plant/Exocarpium Citri Grandis.