Rhein-8-glucoside

Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb. It increases the rate of sennoside A (Cay-24969) metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B, IC50 = 11.5 µM). Rhein-8-glucoside is metabolized to rhein (Cay-17345) by intestinal bacteria.Formal Name: 5-(beta-D-glucopyranosyloxy)-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenecarboxylic acid. CAS Number: 34298-86-7. Synonyms: Rhein 8-O-beta-D-glucopyranoside. Molecular Formula: C21H18O11. Formula Weight: 446.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Slightly soluble. lambdamax: 227, 284, 428 nm. SMILES: O=C1C2=C(C=C(C(O)=O)C=C2O)C(C3=CC=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C31)=O. InChi Code: InChI=1S/C21H18O11/c22-6-12-16(25)18(27)19(28)21(32-12)31-11-3-1-2-8-14(11)17(26)13-9(15(8)24)4-7(20(29)30)5-10(13)23/h1-5,12,16,18-19,21-23,25,27-28H,6H2,(H,29,30)/t12-,16-,18+,19-,21-/m1/s1. InChi Key: WYKUTTFFZMQCGO-HTRBZNBPSA-N. Origin: Plant/Rheum palmatum L..