Rbin-2

Rbin-2 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis. It inhibits the growth of fission yeast strains in vitro (GI50 = 14 nM) and inhibits mdn1 ATPase activity with an apparent EC50 value of approximately 0. µM. InChI: InChI=1S/C13H11BrN4S/c1-7(2)6-19-13-16-12-11(17-18-13)9-4-3-8(14)5-10(9)15-12/h3-5H,1,6H2,2H3,(H,15,16,18) InChIKey: OVDAOBDZJJZJMY-UHFFFAOYSA-N SMILES: BrC1=CC=C2C(NC3=NC(SCC(C)=C)=NN=C32)=C1