Raludotatug

Description: Raludotatug is a humanized immunoglobulin G1-kappa (IgG1kappa) monoclonal antibody that exhibits antineoplastic properties through its specific targeting of cadherin-6 (CDH6), and when conjugated to a cytotoxic payload to form the antibody-drug conjugate Raludotatug deruxtecan.Raludotatug has demonstrated promising research potential in heavily pretreated, platinum-sensitive ovarian cancer. Target: Cadherin. References: Suzuki H, et al. Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models. Mol Cancer Ther. 2024 Mar 4,23(3):257-271.