Raltegravir-d4

Raltegravir-d4 is intended for use as an internal standard for the quantification of raltegravir (Cay-16071) by GC- or LC-MS. Raltegravir is an orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay). It inhibits the spread of HIV-1IIIb infection in MT-4 cell culture with 95% cell culture inhibitory concentration (CIC95) values of 19 and 31 nM in medium containing 10% heat-inactivated fetal bovine serum (FBS) or 50% normal human serum, respectively. Formulations containing raltegravir have been used in combination therapy in the treatment of HIV-1 infection.Formal Name: N-[(4-fluorophenyl-d4)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide. CAS Number: 2712343-38-7. Molecular Formula: C20H17D4FN6O5. Formula Weight: 448.4. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: :, DMSO: soluble. SMILES: O=C(NC(C)(C)C1=NC(C(NCC2=C([2H])C([2H])=C(F)C([2H])=C2[2H])=O)=C(O)C(N1C)=O)C3=NN=C(C)O3. InChi Code: InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)/i5D,6D,7D,8D. InChi Key: CZFFBEXEKNGXKS-KDWZCNHSSA-N.