Rafoxanide

Rafoxanide is an anthelmintic. In vivo, rafoxanide (50 mg/kg) completely eradicates E. caproni infection in mice. It is active against H. contortus in sheep when administered at a dose of 10 mg/kg and eliminates mature F. hepatica flukes in cattle when administered at a dose of 7.5 mg/kg. It is also cytotoxic to A375 and A431 skin cancer cells in vitro (IC50s = 10.9 and 1.31 µM, respectively) and reduces tumor growth in an A375 mouse xenograft model when administered at a dose of 40 mg/kg. Formulations containing rafoxanide have been used in the treatment of parasitic infections in sheep and cattle.Formal Name: N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-benzamide. CAS Number: 22662-39-1. Synonyms: NSC 355278. Molecular Formula: C19H11Cl2I2NO3. Formula Weight: 626.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 30 mg/ml, Ethanol: 2 mg/ml. lambdamax: 222, 338, 386 nm. SMILES: IC1=CC(I)=C(O)C(C(NC2=CC(Cl)=C(OC3=CC=C(Cl)C=C3)C=C2)=O)=C1. InChi Code: InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26). InChi Key: NEMNPWINWMHUMR-UHFFFAOYSA-N.