(R)-PFI-2 (hydrochloride)

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. Its enantiomer, (S)-PFI-2 (Cay-18119), is 500-fold less active (IC50 = 1 µM). See the Structural Genomics Consortium (SGC) website for more information.Formal Name: 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride. CAS Number: 1627607-87-7. Synonyms: (-)-PFI-2. Molecular Formula: C23H25F4N3O3S . HCl. Formula Weight: 536.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.5 mg/ml. SMILES: O=S(C1=CC(CCNC2)=C2C(F)=C1)(N[C@H](CC3=CC(C(F)(F)F)=CC=C3)C(N4CCCC4)=O)=O.Cl. InChi Code: InChI=1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27,/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2,1H/t21-,/m1./s1. InChi Key: ZADKZNVAJGEFLC-ZMBIFBSDSA-N.